• A J Patterson, W J Brown, and D C Roberts.
• Research Centre for Gender and Health, The University of Newcastle, Callaghan, NSW, Australia. whajp@alinga.newcastle.edu.au
• J Am Coll Nutr. 2001 Aug 1;20(4):337-42.

ObjectiveTo examine the effects of iron deficiency and its treatment by iron supplementation or a high iron diet on fatigue and general health measures in women of childbearing age.DesignRandomised controlled trial to compare supplement and dietary treatment of iron deficiency.Subjects44 iron deficient (serum ferritin < 15 microg/L or serum ferritin 15-20 microg/L, plus two of the following: serum iron < 10 micromol/L, total iron binding capacity > 68 micromol/L or transferrin saturation < 15%) and 22 iron replete (hemoglobin > or = 10 g/L and serum ferritin > 20 microg/L) women 18 to 50 years of age were matched for age and parity.InterventionsIron deficient women were randomly allocated to either iron supplementation or a high iron diet for 12 weeks.Measures Of OutcomeIron deficient and iron replete participants had iron studies performed and completed the Piper Fatigue Scale (PFS) and the SF-36 general health and well-being questionnaire at baseline (T0), following the 12 week intervention (T1) and again after a six-month non-intervention phase (T2). The SF-36 includes measures of physical (PCS) and mental (MCS) health and vitality (VT).ResultsMCS and VT scores were lower and PFS scores were higher for iron deficient women (diet and supplement groups) than iron replete women at baseline. Both intervention groups showed similar improvements in MCS, VT and PFS scores during the intervention phase, but mean increases in serum ferritin were greater in the supplement than the diet group. PCS scores were not related to iron status.ConclusionsTreatment of iron deficiency with either supplementation or a high iron diet results in improved mental health and decreased fatigue among women of childbearing age.

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