• Am J Emerg Med · Jun 2022

    Review

    Drug reaction with eosinophilia and systemic symptoms: An emergency medicine focused review.

    • Michael Gottlieb, Matthew R Figlewicz, Willeed Rabah, Devon Buddan, and Brit Long.
    • Department of Emergency Medicine, Rush University Medical Center, USA. Electronic address: michaelgottliebmd@gmail.com.
    • Am J Emerg Med. 2022 Jun 1; 56: 1-6.

    IntroductionDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction associated with potentially severe morbidity and mortality.ObjectiveThis narrative review evaluates the pathogenesis, diagnosis, and management of DRESS for emergency clinicians.DiscussionDRESS is a severe hypersensitivity reaction which can involve multiple organ systems, including the skin, lymphatic system, lungs, kidneys, and heart. Treatment is primarily supportive care combined with removal of the offending agent and initiation of corticosteroids. Additional options include cyclophosphamide, cyclosporine, intravenous immunoglobulin, and N-acetylcysteine.ConclusionIt is important for the emergency clinician to be aware of the diagnosis and management of DRESS in order to best optimize care for these patients.Copyright © 2022 Elsevier Inc. All rights reserved.

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