• Medicina · Mar 2022

    Review

    Metformin: Sex/Gender Differences in Its Uses and Effects-Narrative Review.

    • Ioannis Ilias, Manfredi Rizzo, and Lina Zabuliene.
    • Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, GR-11521 Athens, Greece.
    • Medicina (Kaunas). 2022 Mar 16; 58 (3).

    AbstractMetformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.

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