• Minerva medica · Mar 1987

    Comparative Study

    [Endoscopic evaluation of the effects of diacerhein and naproxen on the gastroduodenal mucosa].

    • G Bianchi Porro, S Ardizzone, I Caruso, and F Montrone.
    • Minerva Med. 1987 Mar 31; 78 (6): 411-3.

    AbstractThe potential capacity of diacerheine (DAR), a new drug known to have no anti-prostaglandin effect and therefore a different action mechanism from the standard non-steroid anti-inflammatory drugs, to cause damage to the gastroduodenal mucosa was compared with that of a well-known NSAID, naproxene. Gastroscopic examination of 10 + 10 patients before and 4 weeks after treatment showed that DAR produced endoscopic lesions without subjective symptoms in 10% of the patients whereas naproxene produced lesions of varying size in 50%, with or without symptoms.

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