• Rev Invest Clin · Jan 2018

    Type 2 Diabetes Mellitus is Associated with Carotid Artery Plaques in Patients with Premature Coronary Heart Disease.

    • J Gabriel Juárez-Rojas, Carlos Posadas-Romero, Rocío Martínez-Alvarado, Esteban Jorge-Galarza, Juan Reyes-Barrera, L Gabriela Sánchez-Lozada, Margarita Torres-Tamayo, and Aida X Medina-Urrutia.
    • Department of Endocrinology. Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
    • Rev Invest Clin. 2018 Jan 1; 70 (6): 301-309.

    BackgroundIn subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events.ObjectiveThe objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients.MethodsPremature CHD was considered before the age of 55 years in men and before 65 in women. T2DM was defined according to the American Diabetes Association criteria. CAP was defined as a focal structure encroaching the arterial lumen by at least 50% of the surrounding IMT value or with a thickness > 1.5 mm.ResultsAmong 1196 patients (CHD duration 1.5 years [interquartile range: 0.4-5.6]), 37.2% had T2DM, and 97.8% were on antihypertensive, 94.4% on lipid-lowering, and 97.3% on anti-aggregate treatment. hCIMT prevalence was similar in patients with or without T2DM, whereas CAP prevalence was higher among T2DM patients (17.7% vs. 30.9%; p < 0.001). T2DM showed association with CAP, independently of CHD evolution and glycemic control (odds ratio: 1.57; 95% confidence interval: 1.09-2.26).ConclusionsT2DM has an independent association with CAP. Early detection of recurrent cardiovascular events, with CAP identification, could be useful to prevent complications in patients with CHD.Copyright: © 2017 SecretarÍa de Salud.

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