• Gen Wu, Qunyan Tian, Jie Liu, Qiong Zhou, Dazhi Zou, Ziyuan Chen, Tong Wu, Wanchun Wang, Hong Xia, and Jian Zhou.
• Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China,Department of Cardiology, The Fourth Hospital ofChangsha, Changsha, Hunan, China,Department of Spine Surgery, Longhui People's Hospital, Shaoyang, Hunan, China,Department of Orthopedics, The FirstPeople's Hospital of Changde City, Changde, Hunan, China,Department of Emergency, The First Hospital of Changsha City, Changsha, Hunan, China,Departmentof Orthopedics, Xiangtan Central Hospital, Xiangtan, Hunan, China.
• Medicine (Baltimore). 2022 Mar 18; 101 (11).

AbstractPrevious studies indicated that lamin proteins were thought to be related to gene expression, chromatin structure, and unclear stability. There are 2 types of vertebrate lamins, including A and B. The 2 B type proteins are encoded by lamin B1 (LMNB1) and lamin B2 (LMNB2). The LMNBs factor has been found to be associated with the development of multiple tumors, but its association with sarcoma has been barely mentioned.The transcription levels of LMNBs were analyzed via Oncomine database. Gene Expression Profiling Interactive Analysis (GEPIA) dataset was adopted to analyze the differential expression of LMNBs in sarcoma. Cancer Cell Line Encyclopedia dataset was used to explore the expression of LMNBs in sarcoma cell line. We analyzed the prognostic value of LMNBs in GEPIA and Kaplan-Meier Plotter. Oncomine and GEPIA datasets were also used to detect the relationship between LMNBs and their co-expressed genes. We used the Database for Annotation, Visualization and Integrated Discovery to conduct the Gene Ontology analysis of LMNBs and their co-expressed genes. Kyoto Encyclopedia of Genes and Genomes was also used to analyze the pathway of LMNBs.LMNB1 and LMNB2 were reported to be hyperexpressed in sarcoma. The expression of LMNBs was elevated in various sarcoma cell lines. According to the results, we observed that LMNBs were connected to the poor overall survival, recurrence-free survival, and disease-free survival of sarcoma patients.This study indicated that hyperexpression of LMNBs was significantly related to worse outcome of sarcoma, LMNB1 and LMNB2 were expected to become potential biomarkers for human.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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