• So Jeong Yoon, Hongbeom Kim, Okjoo Lee, Ji Hye Jung, Chang-Sup Lim, Yong Chan Shin, Wooil Kwon, Jin-Young Jang, Sang Hyun Shin, Jin Seok Heo, and In Woong Han.
• Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea,Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul,South Korea,Department of Surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College ofMedicine, Seoul, South Korea,Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.
• Medicine (Baltimore). 2022 Mar 18; 101 (11).

AbstractRecent studies have reported that inflammatory markers, such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and advanced lung cancer inflammation index, are associated with invasiveness of intraductal papillary mucinous neoplasm (IPMN). This study aimed to develop and validate a new nomogram that includes inflammatory markers for predicting the invasiveness of IPMN.The data of 365 patients who underwent surgical resection for IPMN at 4 centers between 1995 and 2016 were retrospectively reviewed to develop a new nomogram. For external validation, a separate patient cohort was used. The predictive ability of the nomogram was evaluated using the area under the receiver operating characteristic curve.The new nomogram was developed using the following variables which were identified as risk factors for invasive IPMN: body mass index, preoperative serum bilirubin level, carbohydrate antigen 19-9, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, advanced lung cancer inflammation index, main duct type, presence of solid portion, and tumor size. After external validation, the area under the curve value was 0.649 (95% CI: 0.578-0.720, P < .001).To the best of our knowledge, this study is the first to predict and externally validate the invasiveness in IPMN using inflammatory markers. Further research is necessary to improve predictability of the model for selecting patients for surgical resection.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

29 keywords...

hide…