• Bo Wang and Huri Jin.
• Department of Surgery, Yanbian University, Yanji, Jilin, China,Department of Thoracic Surgery Medicine, Affiliated Hospital of Yanbian University, Yanji, Jilin, China.
• Medicine (Baltimore). 2022 Mar 18; 101 (11).

RationaleFetal lung adenocarcinoma (FLAC) is a rare malignant tumor that occurs in the alveolar epithelium. FLAC, as a distinct entity, is a malignancy with a very low incidence, accounting for less than 0.5% of all lung tumors, with a high rate of misdiagnosis due to its rarity, lack of typical presentation and imaging signs. According to histopathological differences, FLAC is further divided into 2 types: low-grade FLAC and high-grade FLAC. In the article, we report a young woman who was diagnosed with low-grade fetal-type lung adenocarcinoma.Patient ConcernsAn 18-year-old female patient was admitted due to cough and chest distress.DiagnosisThe final pathological examination confirmed that the lesion was a low-grade fetal lung adenocarcinoma.InterventionsThe patient underwent thoracoscopic left lower lobectomy and regional lymph node dissection.OutcomesThe postoperative course was stable, and no recurrence was observed 1 year after operation.LessonsTo the best of our knowledge, there are no previous case reports of low-grade fetal-type adenocarcinoma, TP53 gene mutation, and the significance of its mutation is not extensively studies. FLAC, although extremely rare, is considered in the differential diagnosis of lung cancer. In addition, biopsy, histopathology, and specific immunohistochemical staining of larger tissue specimens are helpful for accurate diagnosis of FLAC.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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