• Xiaohua Shi, Yu Bai, Xiaoming He, and Aiguo Wang.
• Department of Minimally invasive Orthopaedics, Zhengzhou Orthopaedic Hospital, Zhengzhou, Henan, China,Department I of Neck, Shoulder, Waist and Leg pain, Zhengzhou Orthopaedic Hospital, Zhengzhou, Henan, China,Department of Preclinical, The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
• Medicine (Baltimore). 2022 Mar 18; 101 (11).

BackgroundAfter reduction and fixation of a fracture around the knee (FAK), excessive injury, improper treatment, soft tissue damage, and blood circulation damage often lead to limb dysfunction, which seriously affects limb rehabilitation and the patient's quality of life. Shaoyao Gancao Decoction (SGD) is an important means of treatment; however, it is not widely applied because of the lack of evidence about the effectiveness of oral drugs in the treatment of limb dysfunction. This study aimed to evaluate the effects of SGD on patients with limb dysfunction from the perspectives of pain, limb edema, stiffness, as well as physical dysfunction.MethodsThe Chinese and English databases, the Wanfang database, Cochrane Library, China National Knowledge Infrastructure, EMBASE, China BioMedical Literature, PubMed, and Web of Science will be searched from inception to September 30, 2021. Both researchers will select the articles, collect the data and evaluate the quality of the methodology independently using the Cochrane bias risk tool.ResultsHigh-quality evidence will be obtained to evaluate the beneficial and detrimental effects of SGD on limb dysfunction after FAK, including knee pain, limb edema, stiffness, and physical dysfunction, as well as adverse events.ConclusionThis study will provide evidence regarding whether SGD is beneficial for treating limb dysfunction after FAK in humans.Inplasy Registration NumberINPLASY202210028.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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