• Nailya R Bulatova, Ayman A Zayed, Ula Qasem Hijjawi, Satani G Sharkas, and Faris G Bakri.
• Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, Jordan,Department of Medicine, School of Medicine, Jordan University Hospital, Amman, Jordan,Infectious Disease and Vaccine Center, The University of Jordan, Amman, Jordan.
• Medicine (Baltimore). 2022 Mar 18; 101 (11).

RationaleThe occurrence of subacute thyroiditis (SAT) after vaccines or after hyaluronic acid skin fillers is very rare and might be related to genetic susceptibility. We suggest that the co-administration of both products could potentially increase the possibility of development of SAT.Patient ConcernsA 58-year-old Caucasian healthy female initially presented with chills, myalgia, dysphagia, sore throat, dry cough, fatigue, and intermittent fever of 38.5°C orally after simultaneous injection of an influenza vaccine and a dermal filler containing hyaluronic acid. Ten days later the patient developed palpitations and neck pain radiating to the left jaw.Diagnosis And InterventionsShe was diagnosed with SAT on day 16 after her first visit and responded promptly to etoricoxib treatment.OutcomesThe patient progressed clinically from hyperthyroidism to euthyroid state and eventually to hypothyroidism and further testing showed she had HLA B-35 haplotype.LessonsPhysicians should be aware that SAT might be associated with the administration an influenza vaccine and this possible association might increase if the vaccine was co-administered with a dermal filler.Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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