• Bonglee Kim, In-Seon Lee, and Seok-Jae Ko.
• Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
• Medicine (Baltimore). 2022 Feb 18; 101 (7): e28892e28892.

BackgroundMetabolic syndrome is a pathological condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Conventional treatments for metabolic syndrome have limitations due to their nonselectivity, drug resistance, and low bioavailability. The brown seaweed Laminaria japonica (LJP) is a traditional medicine and food in Asia that has shown pharmacological and biochemical properties favorable to the prevention and treatment of lifestyle-related diseases. We will systematically review randomized controlled trials and in vivo preclinical studies evaluating the efficacy and safety of LJP as a useful treatment for metabolic syndrome.MethodsThe following databases will be searched from inception to September 2021: MEDLINE (via PubMed), EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science. Randomized controlled trials and in vivo preclinical studies that analyzed LJP for the prevention and treatment of metabolic syndromes will be included. The outcome measures will include body composition, dietary habit scores, serum lipid profiles, daily nutrient intake, quality of life, number of microbiomes, gastrointestinal symptoms, and bowel function. Studies comparing LJP with any type of control intervention will be included. Data extraction using Review Manager version 5.3 and risk of bias assessment using the Cochrane Collaboration's tool for assessing risk of bias will be performed by 2 independent assessors.Results And ConclusionThis systematic review will provide evidence confirming the efficacy and safety of LJP in the treatment of metabolic syndrome.Ethics And DisseminationEthical approval was not required, as this study protocol does not include any personal information of the participants.Trial Registration NumberDOI 10.17605/OSF.IO/G2BQK (https://osf.io/g2bqk).Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

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