• Presse Med · Jan 2003

    Review Comparative Study

    [Aldosterone and its antagonists in heart failure].

    • M E Lopes, P Le Corvoisier, J Y Tabet, J B Su, T Badoual, J C Cachin, P Merlet, A Castaigne, and L Hittinger.
    • Service de cardiologie, Hôpital de Rochefort 16 rue du Dr Peltier 17300 Rochefort.
    • Presse Med. 2003 Jan 18; 32 (2): 79-87.

    AbstractTHE ROLE OF ALDOSTERONE: Aldosterone is the key hormone in salt-water homeostasis. In heart failure, it participates in the appearance and maintenance of signs of congestion. Predominantly synthesised in the glomerular area of the cortico-adrenal glands, extra adrenal production areas have recently been identified notably in the brain, the heart and the large artery trunks. Aldosterone is activated in the cells by the intracellular mineral corticoid receptor. IN CARDIOVASCULAR-PATHOLOGIES: In chronic heart failure, patients treated with conversion enzyme inhibitor may escape from the renin-angiotensin blockade and this may lead to increased aldosterone plasma levels. This increase can induce not only vascular lesions and myocardial fibrosis but also renal and cerebral lesions.

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