• Marie Solignac.
• Presse Med. 2004 May 22; 33 (9 Pt 2): S7-9.

AbstractRADIOLOGICAL EVALUATION CRITERIA: To date, outcome of therapeutic trials examining structure modifying treatments has been basically assessed with repeated measurement of joint spaces on plain x-rays. In the ECHODIAH study, these measurements demonstrated an advantage in favor of treatment with diacerein. Magnetic resonance imaging has not been validated for therapeutic trials. TOTAL ARTHROPLASTY: Total hip replacement has been proposed as an objective evaluation criterion for the efficacy of structure modifying therapy, which raised several criticisms. The PHARE study on the epidemiology of osteoarthritis includes three types of patients referred to orthopedic surgeons for degenerative hip disease and undergoing total hip replacement within three Months. Analysis of data collected should provide a better understanding of the factors leading to implantation of total hip prosthesis in daily practice and help determine the validity of total hip replacement or its indication as the main outcome assessment criterion for therapeutic trials.

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