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Review Case Reports
MELAS and reversible vasoconstriction of the major cerebral arteries.
- Takeshi Yoshida, Atsushi Ouchi, Daisuke Miura, Kunihiro Shimoji, Kazushi Kinjo, Takeshi Sueyoshi, Manabu Jonosono, and Vijay Rajput.
- Department of Neurology, Okinawa Chubu Hospital, Japan. yoshida_takeshi@hosp.pref.okinawa.jp
- Intern. Med. 2013 Jan 1; 52 (12): 1389-92.
AbstractA 26-year-old woman was admitted due to an altered mental status and generalized tonic-clonic seizures. She had experienced chronic migraine-like headaches, progressive bilateral hearing loss, a short stature and nephrotic syndrome. Laboratory data showed elevated lactate and pyruvate levels. Brain MRI using diffusion-weighted imaging revealed a hyperintense lesion in the left temporal lobe. MR angiography revealed segmental stenosis at the C1 and M1-2 junction. A genetic study revealed a mitochondrial DNA A3243G point mutation. The patient's clinical symptoms and MRI/MR angiography (MRA) findings improved within four weeks. We herein discuss the possible pathophysiology involving both stroke-like episodes and reversible vasoconstriction.
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