• Internal medicine · Jan 2013

    Review Case Reports

    Clostridium difficile infection associated with antituberculous agents in a patient with tuberculous pericarditis.

    • Yi-Xuan Sun, Yin-Tao Zhao, Li-Li Teng, Jian-Li Ge, Hua Jiang, and Li Shao.
    • Department of Geriatric Medicine, East Hospital, Tongji University School of Medicine, China.
    • Intern. Med. 2013 Jan 1; 52 (13): 1495-7.

    AbstractClostridium difficile can cause pseudomembranous colitis (PMC). Antimicrobial agent exposure is a risk factor for Clostridium difficile-associated disease, whereas the use of antituberculous (anti-TB) agents is not. We herein report a case of PMC-associated with antituberculous therapy. A 63-year-old woman with tuberculous pericarditis treated with anti-TB agents was admitted for abdominal pain and diarrhea. On colonoscopy, mucoid exudate and yellowish plaque lesions were observed. The anti-TB agents were discontinued, and the patient was treated with metronidazole and clostridium butyricum. Her symptoms were relieved and did not recur when the anti-TB agents were restarted. In this report, we review the literature and discuss the pathogenesis, clinical manifestations, diagnosis and treatment of this case.

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