• Qing Ren, Yongjun Zhang, Jinying Yang, Lixia Wei, Lili Zhao, and Qiaozhi Yang.
• Qing Ren, MD, Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong252000, China.
• Pak J Med Sci. 2015 Jan 1; 31 (1): 656965-9.

ObjectiveTo evaluate renal brush border membrane enzymes in urine as an indicator for renal injury in neonatal scleredema (NS).MethodsSixty nine NS patients in our hospital were enrolled and divided into mild group and moderate/severe group. Patients were further randomly divided into therapy and control subgroups for 7 days ligustrazine administration. Urine samples were collected to detect renal brush border membrane enzymes (RBBME) by ELISA and β2-microglobulin (β2-MG) by radioimmunoassay (RIA). The results were compared with those of 30 normal neonates. Data were statistically analyzed using SPSS13.0 software.ResultsBoth RBBME and β2-MG were found to be higher in urine in NS patients than normal controls (P < 0.01). Level of RBBME increased with the severity of NS (P <0.05), while urinary β2-MG did not (P >0.05). After being treated with ligustrazine, a medicine for renal function recovery, both RBBME and β2-MG were similarly significantly decreased comparing to untreated groups (P < 0.05). 79.7% of NS patients showed abnormal RBBME while only 52.2% had an abnormal urinary β2-MG (χ (2)=11.65，P < 0.01).ConclusionRBBME was more sensitive than β2-MG in reflecting the renal injury in NS. Examination of RBBME effectively reflected the recovery of renal injury after treatment with ligustrazine.

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