• Internal medicine · Oct 2022

    Case Reports

    Unilateral Autoimmune Pulmonary Alveolar Proteinosis with Polymyositis-related Interstitial Lung Disease.

    • Yutaka Muto, Eri Hagiwara, Tomohisa Baba, Yozo Sato, Masashi Sakayori, Erina Tabata, Akimasa Sekine, Shigeru Komatsu, Koji Okudela, Koichi Sayama, and Takashi Ogura.
    • Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.
    • Intern. Med. 2022 Oct 15; 61 (20): 309531003095-3100.

    AbstractA 61-year-old patient with cystic bronchiectasis and bronchial artery hyperplasia in the left lung was diagnosed with polymyositis-related interstitial lung disease. After nine months of immunosuppressive therapy, he developed unilateral autoimmune pulmonary alveolar proteinosis (APAP) in the right lung with respiratory failure. After bronchial artery embolization to prevent massive hemoptysis, whole-lung lavage was performed using veno-venous extracorporeal membrane oxygenation. His respiratory condition improved, and he was discharged from the hospital with supplemental oxygen. Three reported cases of APAP with polymyositis-related interstitial lung disease, including the present case, were all positive for anti-glycyl tRNA synthetase antibody and were under immunosuppressive treatment.

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