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- Tomotaka Yazaki, Kousaku Kawashima, Norihisa Ishimura, Masatoshi Kataoka, Mai Fukunaga, Ryoji Hyakudomi, Yoshitsugu Tajima, Ichiro Moriyama, Asuka Araki, Kyuichi Kadota, Kotaro Shibagaki, Hiroshi Tobita, and Shunji Ishihara.
- Department of Hepatology, Shimane University Faculty of Medicine, Japan.
- Intern. Med. 2022 Nov 1; 61 (21): 322532313225-3231.
AbstractOxaliplatin, widely used as a chemotherapy drug for colorectal cancer, is known to cause various adverse reactions. In particular, special attention for the development of portal hypertension associated with porto-sinusoidal vascular disease is necessary, as it is a serious adverse life-threating reaction, although rare. We herein report a case of oxaliplatin-related portal hypertension that developed several years after oxaliplatin administration and led to esophageal varices and refractory massive ascites. Clinical physicians should be aware of the possibility of oxaliplatin-induced portal hypertension and its possible development over a long period after discontinuation of the drug.
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