• Internal medicine · Jan 2022

    Case Reports

    Safe Concurrent Use of Anti-tuberculosis Drugs and Pembrolizumab in a Patient with Non-small-cell Lung Cancer Who Was Infected with Mycobacterium tuberculosis.

    • Kenji Nakahama, Hiroyasu Kaneda, Koichi Ogawa, Yoshiya Matsumoto, Yoko Tani, Tomohiro Suzumura, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, and Tomoya Kawaguchi.
    • Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan.
    • Intern. Med. 2022 Jan 1; 61 (7): 1039-1042.

    AbstractA 68-year-old Japanese man was diagnosed with lung adenocarcinoma stage IVB. We introduced a first-line chemotherapy of four cycles of carboplatin and pemetrexed and pembrolizumab, followed by pemetrexed and pembrolizumab maintenance therapy. Approximately four months after anticancer therapy, a small nodule appeared in the right peripheral S3 lesion. After five months, the nodule was confirmed as a Mycobacterium tuberculosis (TB) nodule. We initiated anti-TB therapy without stopping pembrolizumab, and the right S3 nodule shrank immediately. This report supports the concurrent use of anti-TB treatment with an immune checkpoint inhibitor when the TB infection area is limited.

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