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- Satoshi Hama, Misako Higashida-Konishi, Mitsuhiro Akiyama, Tatsuya Shimada, Hiroshi Takei, Keisuke Izumi, Hisaji Oshima, and Yutaka Okano.
- Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Japan.
- Intern. Med. 2022 Jan 1; 61 (7): 1085-1091.
AbstractMyositis-specific autoantibody is associated with the clinical phenotype and prognosis of dermatomyositis. Anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl-tRNA synthetase (ARS) antibodies are generally mutually exclusive. We herein present an extremely rare case of dermatomyositis which showed double positivity for anti-MDA5 and anti-ARS antibodies. There have been very few reported cases of double positive anti-MDA5, anti-ARS antibodies. In such cases, the clinical characteristics of each autoantibody can coexist. Thus, we should pay attention to the rapidly progressing features of anti-MDA5 as well as the chronic relapsing features of anti-ARS for the better management of this rare condition.
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