• Med. Clin. North Am. · May 2013

    Review

    The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease.

    • Kaj Blennow and Henrik Zetterberg.
    • Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal Campus, Mölndal, Sweden. kaj.blennow@neuro.gu.se
    • Med. Clin. North Am. 2013 May 1; 97 (3): 369-76.

    AbstractThis article gives an updated account of the clinical application of cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD). The clinically most relevant biomarkers, total tau, phospho-tau and Aβ42 are discussed, and how they may be used, together with other diagnostic investigations, to make a predementia diagnosis of AD. Recent findings in sporadic and genetic preclinical AD are also discussed and, more specifically, what the biomarkers have taught us on the sequence of events in the pathogenic process underlying AD.Copyright © 2013 Elsevier Inc. All rights reserved.

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