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- X Mariette, P Khalifa, P Ravaud, J Frija, M Laval-Jeantet, C Chastang, J C Brouet, and J P Fermand.
- Service d'Immuno-hématologie, Hôpital Saint-Louis, Paris, France.
- Am. J. Med. 1992 Dec 1; 93 (6): 595-8.
Purpose, Patients, And MethodsWe performed dual-energy x-ray absorptiometry in 10 selected patients with aggressive multiple myeloma in whom substantial tumor mass reduction was achieved after high-dose chemoradiotherapy followed by autologous blood stem cell transplantation.ResultsIn most cases, bone mineral density (BMD) of the spine was initially low (Mean Z score: -2.69, SEM 0.76) and dramatically increased after treatment (mean increase 16.4%; 7.7% with 95% confidence interval 2.2 to 12.2, excluding one patient whose spine BMD increased by 94.8%). In contrast, skeletal roentgenograms, computed tomographic scans, and magnetic resonance imaging did not reveal any significant improvement of patients' bone lesions.ConclusionsIn patients with multiple myeloma, bone densitometry could be a useful way to assess the efficacy of treatment on bone status.
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