• Se Hee Min, Anita Phung, Tae Jung Oh, Kyou-Sup Han, Man Jin Kim, Jee Min Kim, Ji Hyun Lee, and Young Joo Park.
• Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
• J. Korean Med. Sci. 2015 Oct 1; 30 (10): 1531-4.

AbstractTherapeutic plasma exchange (TPE) is one possible treatment for patients resistant to conventional antithyroid drugs or requiring urgent attention for thyrotoxicosis. We report a 35-yr-old man with thyrotoxicosis, ultimately attributed to Graves' disease in whom antithyroid drug used initially was soon discontinued, due to abnormal liver function, and replaced by Lugol's solution. Three weeks later, an escape phenomenon (to Lugol's solution) was apparent, so we performed TPE to control the thyrotoxicosis. Two courses of TPE by a centrifugal type machine resulted in diminished levels of thyroid hormone levels, which then rebounded after another two courses of membrane filtration type TPE. However, the patient could be treated with radioactive iodine therapy without any complications at present.

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