• Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Kyusik Kang, Jong-Moo Park, Tai Hwan Park, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Kyung Bok Lee, Myung Suk Jang, Ji Sung Lee, Juneyoung Lee, and Hee-Joon Bae.
• Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
• J. Korean Med. Sci. 2022 Apr 4; 37 (13): e100.

BackgroundClinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients.MethodsUsing a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year.ResultsThis study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever-smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles.ConclusionThe fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.© 2022 The Korean Academy of Medical Sciences.

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