• Manlio F Márquez, José Manuel Fragoso, Daniel Pérez-Pérez, Iris Cázares-Campos, Armando Totomoch-Serra, Jorge Rafael Gómez-Flores, and Gilberto Vargas-Alarcón.
• Department of Electrophysiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City.
• Rev Invest Clin. 2019 Jan 1; 71 (2): 124-132.

BackgroundVasovagal syncope (VVS) is a frequent clinical condition in which a genetic background seems to be implicated. Considering that the adrenergic receptors (ARs) may play a role in VVS, the present study has as principal aim to determine if the α- and β-AR (ADRA and ADRB) gene polymorphisms are associated with an increased risk to have a positive head-up tilt table (HUTT) test in patients with VVS. Methods: Nine polymorphisms in the ADRA1A (rs1048101, rs1383914, rs574584, and rs573542), ADRB1 (rs1801252 and rs1801253), ADRB2 (rs1042713 and rs1042714), and ADRB3 (rs4994) genes were analyzed using the 5' exonuclease TaqMan genotyping assay in a group of 134 patients with VVS.ResultsUnder different models, the rs1801252 (OR = 8.63, 95% CI: 0.95-78.72, Precessive = 0.02), rs1042713 (OR = 1.94, 95% CI: 1.02-3.66, Padditive = 0.04), and rs4994 (OR = 2.46, 95% CI: 1.01-6.01, Pdominant = 0.042 and OR = 2.62, 95% CI: 1.04-6.63, Pover-dominant = 0.03) polymorphisms were associated with increased risk for a positive HUTT. All models were adjusted for statistically significant covariates.ConclusionThese results suggest that some polymorphisms of the β-AR genes could contribute to a positive tilt test in patients with VVS.Copyright: © 2019 SecretarÍa de Salud.

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