• Florin-Andrei Taran, Karl-Oliver Kagan, Markus Hübner, Markus Hoopmann, Diethelm Wallwiener, and Sara Brucker.
• Department of Gynecology and Obstetrics, University Hospital Tübingen.
• Dtsch Arztebl Int. 2015 Oct 9; 112 (41): 693-703; quiz 704-5.

BackgroundExtrauterine pregnancy is a complication of the first trimester of pregnancy that arises in 1.3-2.4% of all pregnancies.MethodsThis review is based on articles and guidelines retrieved by a selective PubMed search.ResultsThe presentation of extrauterine pregnancy is highly variable, ranging from an asymptomatic state, to pelvic pain that is worse on one side, to tubal rupture with hemorrhagic shock. 75% of tubal pre gnancies can be detected by transvaginal ultrasonography. In patients with a vital extrauterine pregnancy, the human chorionic gonadotropin concentration generally doubles within 48 hours. Laparoscopy is the gold standard of treatment. Two randomized, controlled trials comparing organ-preserving treatment with ablative surgery revealed no significant difference in pregnancy rates after the intervention, but precise details of the surgical procedures were not provided, and long-term fertility data are lacking. Metho - trexate therapy should be used only for strict indications.ConclusionFurther randomized, controlled trials with longer follow-up will be needed to answer currently open questions about the potential for individualized surgical treatment and the proper role of pharmacotherapy.

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