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American family physician · Sep 2000
Review Comparative StudySickle cell disease in childhood: Part II. Diagnosis and treatment of major complications and recent advances in treatment.
- D L Wethers.
- St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
- Am Fam Physician. 2000 Sep 15; 62 (6): 1309-14.
AbstractTreatment advances over the past 25 years have significantly decreased morbidity and mortality in children with sickle cell disease. Aggressive management of fever, early diagnosis of acute chest syndrome, judicious use of transfusions and proper treatment of pain can improve quality of life and prognosis for these children. Prophylactic hydroxyurea therapy has been shown to reduce the incidence and severity of pain crises in adults with sickle cell disease and has been effective in limited studies conducted in children. Research into stem cell transplantation provides hope that a cure for sickle cell disease may be possible.
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