• J Chin Med Assoc · Mar 2015

    Review

    Preventive and therapeutic role of traditional Chinese herbal medicine in hepatocellular carcinoma.

    • Chin-Tsung Ting, Wan-Chun Li, Chang-Yi Chen, and Tung-Hu Tsai.
    • Division of Gastrointestinal Surgery, Department of Surgery, Taipei City Hospital (Renai Branch), Taipei, Taiwan, ROC; Institute of Traditional Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
    • J Chin Med Assoc. 2015 Mar 1; 78 (3): 139-44.

    AbstractHepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. The clinical management of HCC remains a substantial challenge. Although surgical resection of tumor tissues seems promising, a high recurrence and/or metastasis rate accounting for disease-related death has led to an urgent need for improved postsurgical preventive/therapeutic clinical intervention. Developing advanced target-therapy agents such as sorafenib appears to be the only effective clinical intervention for patients with HCC to date, but only limited trials have been conducted in this regard. Because of their enhanced preventive/therapeutic effects, traditional Chinese herbal medicine (CHM)-derived compounds are considered suitable agents for HCC treatment. The CHM-derived compounds also possess multilevel, multitarget, and coordinated intervention effects, making them ideal candidates for inhibition of tumor progression and HCC metastasis. This article reviews the anticancer activity of various CHMs with the hope of providing a better understanding of how to best use CHM for HCC treatment. Copyright © 2014. Published by Elsevier Taiwan.

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