• Emma Mares-García, Antonio Palazón-Bru, Álvaro Martínez-Martín, Folgado-de la RosaDavid ManuelDMa Department of Clinical Medicine , Miguel Hernández University , San Juan de Alicante , Alicante , Spain., Avelino Pereira-Expósito, and Vicente Francisco Gil-Guillén.
• a Department of Clinical Medicine , Miguel Hernández University , San Juan de Alicante , Alicante , Spain.
• Curr Med Res Opin. 2017 Oct 1; 33 (10): 1725-1729.

ObjectivesTo determine the magnitude of non-guideline-recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in the general population, its associated factors and expense.MethodsWe undertook a cross-sectional observational study in three community pharmacies in a Spanish region in 2013 involving a total of 302 patients with a prescription for PPIs. The main variable was the NGRP of PPIs. Secondary variables were: gender, age, antidepressants, osteoporosis, osteoarthritis, prescription cost per month and total number of chronic diseases. The cost associated with NGRP was calculated. To evaluate the associated factors, a multivariate binary logistic regression model was constructed and the adjusted odds ratios (OR) were obtained.ResultsNGRP was observed in 192 cases (63.6%). The average cost associated with NGRP per prescription was 3.24 euros per month. The factors significantly associated with NGRP (p < .05) were: antidepressants (OR = 2.66, p = .001), osteoporosis (OR = 3.53, p = .001), osteoarthritis (OR = 3.57, p < .001) and number of chronic diseases (OR = 0.73, p = .003).ConclusionA novel approach was used to quantify the NGRP of PPIs in a Spanish community, as well as the associated economic costs. Qualitative studies are needed to better understand the causes of NGRP of PPIs. This analysis will aid in designing interventions to minimize this problem.LimitationsQualitative studies are needed to better understand the attitude of health professionals when prescribing PPIs.

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