• Ritam Chowdhury, Amita Mukhopadhyay, William McClellan, Stefanie Sarnat, Lyndsey Darrow, and Kyle Steenland.
• Department of Epidemiology (RC, WM, LD, KS), James T. Laney School of Graduate Studies, Emory University, Atlanta, Georgia; Department of Biostatistics (RC), Harvard School of Public Health, Boston, Massachusetts; Department of Community Medicine (AM), Bangalore Medical College and Research Institute, Bangalore, India; and Department of Environmental Health (SS, KS), Rollins School of Public Health and James T. Laney School of Graduate Studies, Emory University, Atlanta, Georgia.
• Am. J. Med. Sci. 2015 Mar 1; 349 (3): 222-7.

BackgroundOne previous study has shown that patients with end-stage renal disease (ESRD) with higher blood lead levels (BLLs) have shorter survival, in a cohort without occupational exposure where follow-up began an average of 5 years after dialysis (a survivor population).MethodsThe authors studied individuals with at least 1 blood lead test who were part of an occupational lead surveillance program sponsored by the National Institute for Occupational Safety and Health and were diagnosed with ESRD. The authors studied the effect of BLL on survival from time of ESRD diagnosis after adjusting for potential confounders. Cox proportional hazards models were run, in which death was the end point and follow-up time was the time variable.ResultsThere were 434 ESRD cases with 82% males, 65% white and 31% African American; 51% had 1 blood test, whereas the remainder had a median of 5 tests. The median years of follow-up were 2.7 years with 219 deaths in the cohort. After adjusting for covariates (eg, transplantation status, age at diagnosis, glomerular filtration rate, comorbidities and ethnicity), the authors found no significant association between highest measured BLL and mortality across categories; 0 to <5 μg/dL (hazard ratio [HR] = 1.00), 5 to <25 μg/dL (HR = 1.09; 95% confidence interval [CI]: 0.70-1.70), 25 to <40 μg/dL (HR = 1.28; 95% CI: 0.81-2.02), 40 to <50 μg/dL (HR = 0.89; 95% CI: 0.48-1.63) and 50+ μg/dL (HR = 1.09; 95% CI: 0.66-1.81).ConclusionsThe authors found no association between BLL and survival after ESRD diagnosis. The authors' finding differs from earlier findings, possibly because the cohort had higher blood leads (25 versus 10 μg/dL), follow-up began at the time of ESRD diagnosis, and BLLs were measured before ESRD incidence.

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