• Fenfen Peng, Xuexin Lin, Ling Zhi Sun, Weidong Zhou, Yihua Chen, Peilin Li, Ting Chen, Jiayu Wu, Zhaozhong Xu, and Haibo Long.
• Department of Nephrology.
• Medicine (Baltimore). 2019 Jul 1; 98 (28): e16244.

RationaleThe incidence exercise-induced rhabdomyolysis is increasing in the healthy general population. Rhabdomyolysis can lead to the life-threatening systemic complications of acute kidney injury (AKI), compartment syndrome, and disseminated intravascular coagulopathy.Patient ConcernsA 21-year-old man had bilateral lower limb pain and soreness, dark brown urine after lower exremity training. Laboratory results showed that creatinine kinase (CK) and myoglobin (Mb) increased to 140,500 IU/L and 8632 μg/L respectively, with elevated liver enzymes, Scr, and proteinuria.DiagnosesExercise-induced rhabdomyolysis with AKI.InterventionsThe patient was hospitalized and treated with vigorous hydration and sodium bicarbonate for 6 days.OutcomesAfter 6 days of treatment, the patient had a significant decrease in the CK and Mb levels. His renal function returned to normal. His laboratory tests had completely normalized during 2-week follow-up.LessonsExercise-induced rhabdomyolysis can cause serious complications such as AKI. Delayed diagnosis can be critical, so timely manner should be taken to achieve a favorable prognosis.

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