• Xuewei Wang, Peng Wang, Hao Su, Jianwei Liang, Haitao Zhou, and Zhixiang Zhou.
• Department of Colorectal Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
• Medicine (Baltimore). 2019 Jul 1; 98 (29): e16377.

RationaleSmall intestine stromal tumors (SISTs) are a type of gastrointestinal stromal tumor (GIST) that has an insidious onset. Natural orifice specimen extraction (NOSE) surgery has been gradually developed for the treatment of colorectal, stomach, small intestine, hepatobiliary, and gynecological tumors because of its safety and feasibility. This case study explored the possibility of applying the NOSE method for the treatment of SIST.Patient ConcernsA 59-year-old male patient was admitted to the hospital after having an irregular abdominal mass for >1 month that was detected by a medical examination. Thoracic and abdominopelvic enhanced computer tomography revealed irregular masses on the left side of the abdominal cavity.DiagnosisSist.InterventionsNose (laparoscopic resection of intestinal stromal tumors with transrectal extract specimen and no abdominal auxiliary incision) surgery was performed.OutcomesThe patient underwent operation successfully and recuperates well with no complications.LessonsNose surgery is minimally invasive, results in patient recuperation with no complications, and is considered to be feasible for SIST treatment.

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