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- Tomoka Nakamura, Tetsuro Tsujimoto, Kazuki Yasuda, Daisuke Chujo, Mitsuru Ohsugi, Akiyo Tanabe, Kohjiro Ueki, and Hiroshi Kajio.
- Department of Diabetes, Endocrinology, and Metabolism, Center Hospital.
- Medicine (Baltimore). 2019 Jul 1; 98 (30): e16573.
RationalePrevious studies have suggested that increased levels of advanced glycation end products (AGEs) and soluble receptor for AGE (sRAGE) are associated with diabetes-related complications. However, there is little evidence on the association between long-term levels of AGEs and sRAGE and progression of diabetes-related complications.Patient ConcernsA 64-year-old man had poorly controlled type 2 diabetes, obesity, smoking, hypertension, and dyslipidemia. He had many risk factors for diabetes-related complications.DiagnosisDespite poor glycemic control over 15 years, the patient did not exhibit diabetes-related complications.InterventionsWe examined serum AGEs (CEL and MG-H1) and sRAGE levels in this patient over the past 10 years.OutcomesThe patient maintained low serum AGEs and sRAGE levels.LessonsAGEs and sRAGE levels may be associated with long-term development of diabetes-related complications.
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