• Blood · Apr 2002

    Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis.

    • Jean-François Viallard, Anne Solanilla, Bruno Gauthier, Cécile Contin, Julie Déchanet, Christophe Grosset, Jean-François Moreau, Vincent Praloran, Paquita Nurden, Jean-Luc Pellegrin, Alan T Nurden, and Jean Ripoche.
    • Department of Internal Medicine, Hôpital Haut-Lévêque, 5 avenue Magellan, 33604 Pessac, France. jean-francois.viallard@chu-bordeaux.fr
    • Blood. 2002 Apr 1;99(7):2612-4.

    AbstractCD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thrombocythemia (ET). A tight correlation was found between the platelet count and plasma sCD40L. ET patients had the highest levels of sCD40L. Platelet-associated CD40L was increased in ET and reactive thrombocytosis, conditions associated with increased platelet regeneration. Platelet-associated CD40L was released upon platelet activation. In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration.

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