• Eur. J. Clin. Invest. · Apr 2012

    Homogenous phenomenon of graft liver CYP2C19 genotypes after living donor liver transplantation.

    • King-Wah Chiu, Toshiaki Nakano, Tsung-Hui Hu, Hui-Peng Tseng, Yu-Fan Cheng, Bruno Jawan, Hock-Liew Eng, Shigeru Goto, and Chao-Long Chen.
    • Liver Transplant Program, Chang Gung Memorial Hospital-Kaohsiung Medical Center and Chang Gung University College of Medicine, Taiwan, China.
    • Eur. J. Clin. Invest. 2012 Apr 1; 42 (4): 352-6.

    BackgroundThe donor liver grafts with different allelic patterns do not affect CYP2C19 genotypes in the peripheral blood of living donor liver transplantation (LDLT) recipients.AimThis study investigated the influence of graft liver CYP2C19 genotypes on recipients who received the same or different CYP2C19 genotypes from donors after LDLT.MethodsThere were 30 donors and 30 recipients with the same CYP2C19 genotypes and 47 donors and 47 recipients with different CYP2C19 genotypes. Genomic DNA was isolated from the liver tissue of recipients. The CYP2C19 haplotypes were determined by polymerase chain reaction.ResultsA homogenous phenomenon in the sequences of graft liver CYP2C19 genotypes was indicated because the recipients showed mixed patterns that were similar to that of the original donor after LDLT. A significant decrease in homozygous extensive metabolizer (HomEM) and an increase in poor metabolizer (PM) distribution were observed in recipients with different CYP2C19 genotypes from their donors compared with recipients with the same CYP2C19 genotype as their donors (P < 0·05).ConclusionsHomogenous phenomenon of sequence changes in graft liver CYP2C19 from the different genotypes between the donors and the recipients may play a role in graft stability by causing decreased HomEM and increased PM after LDLT.© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.

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