• Eur. J. Clin. Invest. · Oct 2014

    FNDC5 could be regulated by leptin in adipose tissue.

    • Carolina Gutierrez-Repiso, Sara Garcia-Serrano, Francisca Rodriguez-Pacheco, Eva Garcia-Escobar, Juan J Haro-Mora, Juan Garcia-Arnes, Sergio Valdes, Montserrat Gonzalo, Federico Soriguer, Francisco J Moreno-Ruiz, Alberto Rodriguez-Cañete, Abelardo Martinez-Ferriz, Julio S Santoyo, Vidal Perez-Valero, and Eduardo Garcia-Fuentes.
    • Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain.
    • Eur. J. Clin. Invest. 2014 Oct 1; 44 (10): 918-25.

    IntroductionIrisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.Material And MethodsWe measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.ResultsSerum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0·043) and after bariatric surgery (P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist-to-hip ratio (WHR) (R(2) = 0·201) (Beta = -0·357, P = 0·046). Those morbidly obese subjects with android-type obesity had lower serum irisin levels than those with gynecoid-type obesity, both before (P = 0·027) and after bariatric surgery (P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = -0·529, P = 0·005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0·009 and P = 0·037, respectively).ConclusionsWe showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin.© 2014 Stichting European Society for Clinical Investigation Journal Foundation.

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