• Ana F Branco, André Ferreira, Rui F Simões, Sílvia Magalhães-Novais, Cheryl Zehowski, Elisabeth Cope, Ana Marta Silva, Daniela Pereira, Vilma A Sardão, and Teresa Cunha-Oliveira.
• CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
• Eur. J. Clin. Invest. 2016 Mar 1; 46 (3): 285-98.

BackgroundThe employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of high fat, moderate protein and low carbohydrates, which favour mitochondrial respiration rather than glycolysis for energy metabolism.DesignThis review focuses on how oncological, neurological and mitochondrial disorders have been targeted by ketogenic diets, their metabolic effects, and the possible mechanisms of action on mitochondrial energy homeostasis. The beneficial and adverse effects of the ketogenic diets are also highlighted.Results And ConclusionsAlthough the full mechanism by which ketogenic diets improve oncological and neurological conditions still remains to be elucidated, their clinical efficacy has attracted many new followers, and ketogenic diets can be a good option as a co-adjuvant therapy, depending on the situation and the extent of the disease.© 2016 Stichting European Society for Clinical Investigation Journal Foundation.

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