• Paloma Almeda-Valdés, Omar Y Bello-Chavolla, César R Caballeros-Barragán, Donají V Gómez-Velasco, Tania Viveros-Ruiz, Arsenio Vargas-Vázquez, and Carlos A Aguilar-Salinas.
• Departamento de Endocrinología y Metabolismo, Ciudad de México, México.
• Gac Med Mex. 2018 Jan 1; 154 (Supp 2): S50S55S50-S55.

ObjectiveTo evaluate the correlation between subrogate index for the evaluation of insulin resistance with the M value obtained with the euglycemic-hyperinsulinemic clamp as well as their sensitivity, specificity, and positive and negative predictive values.MethodThe euglycemic-hyperinsulinemic clamp was performed in subjects having both normal fasting glucose and glycated hemoglobin concentrations. HOMA-IR, QUICKI, HOMA2%S, TyG, TyG*body mass index (BMI) and triglyceride/HDL indexes were calculated. Correlations coefficients were estimated between indexes results and the M-value adjusted by fat-free mass. Areas under the ROC curve were constructed to evaluate overall performance, sensitivity, specificity and predictive values of the subrogate indexes.Results57 subjects, 68.4% women, with a mean age of 32.9 ± 11 years-old were included. The subrogate index with the best correlation with the M value was HOMA2%S (r = 0.428), HOMA-IR had the greatest area under the ROC curve (0.683; 95 % confidence interval: 0.503-0.864) and TyG*BMI the best sensitivity (98.2 %) and specificity (51.1 %).ConclusionsThe surrogated indexes for the evaluation of insulin resistance show a significant correlation with the M value obtained with the gold standard. Additional studies are required to determine cut-off values in Mexican population.Copyright: © 2018 SecretarÍa de Salud.

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