• Ashuin Kammar-García, Patricia López-Moreno, María Elena Blásquez-Gutiérrez, María Elena Hernández-Hernández, Angélica María Ortiz-Bueno, and María de Lurdez Consuelo Martínez-Montaño.
• Benemérita Universidad Autónoma de Puebla, Departamento de Bioquímica, Puebla, Puebla, México.
• Gac Med Mex. 2019 Jan 1; 155 (3): 236-242.

IntroductionHyperuricemia is a risk factor for cardiovascular disease, but its impact has not been properly documented.ObjectiveTo assess the impact of hyperuricemia on metabolic parameters and cardiovascular risk factors (CRF) in apparently healthy Mexicans.MethodCross-sectional study of 768 young adults. Association of hyperuricemia with alterations in metabolic parameters and CRF (hypertension, mixed dyslipidemia, metabolic syndrome) was sought. Log-linear and regression models were used to determine the influence of hyperuricemia. A multivariate analysis of variance was applied to observe the interaction of hyperuricemia and overweight or obesity with changes in metabolic parameters.ResultsMetabolic parameters were higher in patients with hyperuricemia than with normal uric acid (all < 0.05). Hyperuricemia was significantly associated with hypertension (OR=6.8, 95 % CI: 1.1-46), dyslipidemia (OR=2.5, 95% CI: 1.3-4.7) and metabolic syndrome (OR=2.3, 95% CI: 1.1-4.6). Hyperuricemia and overweight or obesity significantly predict changes in cardiovascular risk metabolic parameters (Wilks' l=0.91, F (6.175)=3.1, p=0.007).ConclusionsHyperuricemia is significantly associated with metabolic alterations and different CRF.Copyright: © 2019 SecretarÍa de Salud.

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