• Gac Med Mex · Jan 2019

    Alelos HLA más comunes y asociados con riesgo o protección en enfermedad renal crónica de etiología no determinada.

    • Juan Carlos H Hernández-Rivera, Mariana Salazar-Mendoza, María Juana Pérez-López, Jaime González-Ramos, Ramón Espinoza-Pérez, Julio César Martínez-Álvarez, Miguel Trejo-Villeda, and Ramón Paniagua-Sierra.
    • Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Nefrológicas. Ciudad de México, México.
    • Gac Med Mex. 2019 Jan 1; 155 (3): 243-248.

    IntroductionChronic kidney disease accounts for part of overall health expenditure; a potential etiology is related to variations, absence or presence of some human leukocyte antigen (HLA) alleles.MethodAn analysis of HLA reports of 1965 kidney recipients with no determined etiology, and 1361 kidney donors was performed. It was carried out with Luminex based in cell flow fluorometry for the A, B, DRB1 and DQA loci. An analysis was performed with contingency tables in order to determine the odds ratio (OR) and confidence intervals (CI). Quantitative analysis was also carried out.ResultsOf the 101 alleles found, 13 showed association, 7 with risk for chronic kidney disease, with the most significant being HLA-DR17 with an OR of 3.91 (95 % CI = 2.96-5.17) and the one with the highest significance for protection being HLA-DR9, with an OR of 0.043 (95 % CI = 0.005-0.3224).ConclusionsIt is necessary to understand that kidney diseases can be associated with yet unknown immune processes, where the association of the absence or presence of any allele should be known.Copyright: © 2019 SecretarÍa de Salud.

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