• Celina Trujillo-Esteves, Nadia Helena Mayoral-Flores, Bernardo Soto-Rivera, and José Vicente Rosas-Barrientos.
• Anesthesiology Department. Hospital Regional 1o. de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, City of Mexico, Mexico.
• Gac Med Mex. 2019 Jan 1; 155 (Suppl 1): S13-S16.

BackgroundPreventive analgesia is the administration of an analgesic drug with the aim of attenuating post-operative pain, hyperalgesia and allodynia. Its use is justified in order to offer analgesia and reduce anxiety in patients undergoing laparoscopic procedures.ObjectiveTo evaluate if pregabalin in a dose of 1 mg/kg of weight is effective as preventive analgesia in post-operated laparoscopic cholecystectomy patients.MethodsA single-blind controlled clinical trial was conducted, which included 60 patients scheduled for laparoscopic cholecystectomy randomly divided into 2 groups, where Group 1 received placebo and Group 2 received pregabalin a daily dose 72 h prior to surgical intervention. The intensity of pain was assessed using the numeric analog scale at 1, 2, 6, 12 and 24 post-operative h, as well as the level of presurgical anxiety with the Hamilton scale.ResultsPain reduction was demonstrated in patients in the pregabalin group from the 1st h (p = 0.002), later the decrease in pain was more noticeable compared to patients who were given placebo (p < 0.001), the same happened with the anxiety level evaluated with the Hamilton scale (p < 0.005).ConclusionThe use of pregabalin as preventive analgesia turns out to be effective in the post-operative period and the pre-operative anxiety with minimal adverse effects in the post-operated patients of laparoscopic cholecystectomy.Copyright: © 2019 Permanyer.

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