• Indian J Med Res · Mar 2016

    Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus.

    • Soumyadeep Ghosh and Mandira Banerjee.
    • Department of Microbiology, Nilratan Sircar Medical College & Hospital, Kolkata, India.
    • Indian J Med Res. 2016 Mar 1; 143 (3): 362-4.

    Background & ObjectivesMethicillin resistant Staphylococcus aureus (MRSA) isolates with inducible clindamycin resistance (iCR) are resistant to erythromycin and sensitive to clindamycin on routine testing and inducible clindamycin resistance can only be identified by D-test. This study was aimed to detect methicillin resistance and iCR among S. aureus isolates, effectiveness of some commonly used antibiotics and correlation between methicillin resistance and iCR.MethodsThe present cross-sectional study included 46 S. aureus isolates subjected to Kirby-Bauer's disk diffusion method for antibiotic susceptibility testing (AST) to estimate MRSA and resistance to some commonly used antibiotics. D-test was employed to detect iCR.ResultsEleven of the 46 (23.9%) isolates tested were MRSA. Overall, 19 (41.3%) isolates showed of iCR. Vancomycin and linezolid were found to be 100 per cent effective. A positive Karl-Pearson's coefficient of correlation (0.89) between methicillin resistance and iCR was obtained.Interpretation & ConclusionsDetection of iCR is important for the use of clindamycin in MRSA infections. Methicillin resistance and iCR appear to be clinically unrelated.

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