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- P J le Roux and J F Coetzee.
- Department of Anesthesiology, University of Stellenbosch, Tygerberg, South Africa. pjlr@maties.sun.ac.za
- Curr Opin Anaesthesiol. 2000 Aug 1; 13 (4): 457-61.
AbstractTramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs in the treatment of moderate postoperative pain and to abolish shivering. It may have advantages in paediatric and day-case surgery and as an adjunct in local anaesthetic techniques. This review provides an evidence-based account of the role of tramadol in modern practice.
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