• Ellen Jørum.
• Department of Physiology, University of Göteborg, GöteborgSweden.
• Pain. 1988 Mar 1; 32 (3): 341-348.

AbstractAnalgesia following exposure to a variety of noxious and non-noxious stressors is well documented and is commonly referred to as stress-induced analgesia. Hyperalgesia following stress has also been reported. The present study shows that a mild stressor (15 min of vibration) produced increased tail-flick latencies (TFL) in some rats, but decreased latencies in other rats. The results of the individual subjects were reproduced in a later session: the rats showing increased TFL on day 1, responded with increased TFL on day 2. Rats showing decreased TFL on day 1 responded with decreased TFL on day 2. Whichever reaction occurred, analgesia or hyperalgesia, this correlated with the animal's behavior during the stress procedure. Analgesia was produced in quiet rats and hyperalgesia in hyperemotional ones. Various peripheral nerve stimulation procedures producing hyperemotional reactions also resulted in lowering of the pain threshold. The results of the present study show behavioral modulation of pain mechanisms.

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