• Med Klin · Mar 2007

    Case Reports

    [Leydig cell tumor as a cause of hirsutism in a postmenopausal woman].

    • Anna Matuszczyk, Stephan Petersenn, Harald Lahner, Michael Haude, Patrick Veit, Jan U Becker, Rainer Kimmig, Andreas Bockisch, and Klaus Mann.
    • Klinik für Endokrinologie, Universitätsklinikum Essen, Essen, Deutschland. anna.matuszczyk@gmx.de
    • Med Klin. 2007 Mar 15; 102 (3): 259-62.

    BackgroundHirsutism or virilization in postmenopausal women may be due to increased testosterone levels caused by an androgen-secreting tumor. The preoperative localization of small ovarian or adrenal androgen-secreting tumors is difficult.Case ReportA 61-year-old, postmenopausal woman presented with progressive hirsutism and deepening of voice over the last 9 years. Serum testosterone was very high (almost 30 nmol/l). Computed tomographic (CT) scans of the adrenals and ultrasonography of the pelvis were negative. Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary. Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination.ConclusionSelective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.

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