• Clin Med (Lond) · Feb 2017

    Review

    ANCA-associated vasculitis.

    • Max Yates and Richard Watts.
    • Norfolk and Norwich University Hospital NHS Foundation Trust, and Norwich Medical School, University of East Anglia, Norwich, UK.
    • Clin Med (Lond). 2017 Feb 1; 17 (1): 606460-64.

    AbstractThe vasculitides are a heterogeneous group of conditions typified by their ability to cause vessel inflammation with or without necrosis. They present with a wide variety of signs and symptoms and, if left untreated, carry a significant burden of mortality and morbidity. The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are three separate conditions - granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome). This review examines recent developments in the pathogenesis and treatment of AAV, focusing on developments in treatment following the introduction of rituximab, in particular.© Royal College of Physicians 2017. All rights reserved.

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