• Tai-Yuan Su, Wei-Ting Ho, Shu-Chiung Chiang, Chien-Yi Lu, Huihua Kenny Chiang, and Shu-Wen Chang.
• Department of Electrical Engineering, Yuan-Ze University, Chung-Li, Taoyuan, Taiwan.
• J Formos Med Assoc. 2017 Jul 1; 116 (7): 554-559.

Background/PurposeTo evaluate meibomian gland dysfunction (MGD) by infrared thermography.MethodsAn observational study was conducted at the Department of Ophthalmology, Far Eastern Memorial Hospital, New Taipei City, Taiwan. Participants included 89 MGD patients (30 in Grade 1, 49 in Grade 2, and 10 in Grade 3) and 65 controls. The close-eye thermographic images of the eyelid were obtained noninvasively by infrared thermography. Temperatures at 8 regions of interest (ROIs) of the eyelid margin and a reference temperature at the center of the upper eyelid were measured. The temperature ratio was defined as the temperature of ROI divided by the reference temperature.ResultsEyelid margin temperature measured by infrared thermography increased from temporal side (ROI 1) to the nasal side (ROI 8) of the eye in both MGD patients and control groups. The temperature ratios were significantly higher in MGD participants than in controls, especially at ROI 8.ConclusionThe eyelid margin temperature measured by infrared thermography was higher in MGD participants. Further development of this infrared thermography system may become a rapid and non-invasive tool for MGD screening.Copyright © 2016. Published by Elsevier B.V.

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