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Internal medicine journal · Apr 2022
Prior oral proton-pump inhibitor use is associated with reduced severity of aspirin-related upper gastrointestinal bleeding in older people.
- Oyekoya T Ayonrinde, Natasha Walldorf, Nicholas Chan, Nathanael Y Foo, Tithi Kulkarni, John K Olynyk, and Frank M Sanfilippo.
- Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Perth, Western Australia, Australia.
- Intern Med J. 2022 Apr 1; 52 (4): 663-666.
AbstractLow-dose aspirin is commonly used for primary or secondary prophylaxis against cardiovascular disease in older people. However, the potential risk of upper gastrointestinal (UGI) ulceration and bleeding associated with low-dose aspirin use is often not appreciated by prescribers and older consumers. Among 133 serial patients with UGI bleeding, aspirin-users aged ≥70 years had a ninefold increased likelihood of overt UGI bleeding compared with non-users, reducing by 90% in regular proton-pump inhibitor users (adjusted odds ratio 0.10). We recommend risk-versus-benefit discussions when recommending aspirin to older people.© 2022 Royal Australasian College of Physicians.
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