• Mohammed A Munim, Alexander J Butler, Ira J Miller, and Matthew W Colman.
• Depeartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.
• World Neurosurg. 2022 Jul 1; 163: e539-e548.

Background And ObjectivesParagangliomas are rare neuroendocrine tumors that may localize to the spine causing progressive low back pain variably accompanied by radiculopathy. Recurrence, follow-up duration, and role of adjuvant therapy remain unestablished.MethodsWe interrogated our institution's histopathology database for all confirmed cases of spinal paraganglioma between 2000 and 2021. Patient records were retrospectively reviewed to extract diagnostic features, operative treatment, and follow-up outcomes.Results6 cases of spinal paraganglioma were surgically treated (67% female vs. 33% male, mean age = 51.3 years). Preoperative symptom duration did not correlate with tumor size (Spearman r = 0.154, P = 0.80). The mean postoperative follow-up duration lasted 3.3 years (range = 2-96 months). There were an equal number of primary and metastatic lesions. 1 tumor exhibited secretory features and was consequently embolized preoperatively. No residual or recurrent disease was evident in the primary cases; however, 2 metastatic cases recurred within 2 years of surgery and 1 patient died.ConclusionsGiven nonspecific clinical and radiologic features, spinal paragangliomas are diagnosed via biopsy or after surgery. Complete surgical resection is often necessary to alleviate symptoms and prevent tumor recurrence. In cases with benign metastases, long-term surveillance is important and adjuvant medical and radiotherapeutic treatment may be beneficial.Copyright © 2022 Elsevier Inc. All rights reserved.

16 keywords...

hide…