• Ying Wu, Hongyan Du, Pippa Storey, Christopher Glielmi, Fiona Malone, Shawn Sidharthan, Ann Ragin, Paul S Tofts, and Robert R Edelman.
• Radiology, NorthShore University HealthSystem, Evanston, Illinois 60201, USA. YWu@northshore.org
• J Magn Reson Imaging. 2012 Feb 1;35(2):309-17.

PurposeTo enhance the reliability and spatial resolution of magnetization transfer ratio (MTR) measurements for interrogation of subcortical brain regions with an automated volume of interest (VOI) approach.Materials And MethodsA 3D magnetization transfer (MT) sequence was acquired using a scan-rescan imaging protocol in nine healthy volunteers. VOI definition masks for the MTR measurements were generated using FreeSurfer and compared to a manual region of interest (ROI) approach. (The longitudinal stability of MTR was monitored using agar gel phantom over a 5-month period.) Intraclass correlation coefficients (ICCs), coefficients of variation (CVs), and instrumental standard deviation (ISD) were determined.ResultsCVs ranged from 1.29%-2.64% (automated) vs. 1.30%-3.40% (manual). ISDs ranged from 0.62-1.10 pu (automated) vs. 0.68-1.67 pu (manual). The SD of the running difference was 1.70% for the phantom scans. The Bland-Altman method indicated interchangeability of the automated VOI and manual ROI measurements.ConclusionThe automated VOI approach for MTR measurement yielded higher ICCs, lower CVs, and lower ISDs compared to the manual method, supporting the utility of this strategy. These results demonstrate the feasibility of obtaining reliable MTR measurements in hippocampus and other critical subcortical regions.Copyright © 2011 Wiley Periodicals, Inc.

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